Lattice Medical

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TECHNOLOGY

Lattice Medical is a biomedical start-up that was launched in October 2017
Patented 3D technology developed with CHU Lille-France that allows adipose tissue to naturally regenerate

Breast cancer touch 1 in 8 women in the world In 40% of cases, mastectomy is the usual treatment followed by chemotherapy or radiotherapy
Only 14% of women receive reconstructive surgery
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Reconstruction procedure offered are:
silicon prosthesis, autologous fat tissues grafting by microsurgical technics (DIEP) or non-vascularise transfer (lipofilling).

These methods show different issues such as multiple surgical procedure, complications and costs for healthcare system, limiting the availability for patients.
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LATTICE MEDICAL, valorising 6 research years from CHU Lille, comes up with an innovative technical solution combining the advantages of current techniques, thereby simplifying the process and making it more accessible and less expensive: a 3D printed bioabsorbable implant called MATTISSE.
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The technology involves the use of autologous adipose tissue as a base, and then combines this with a 3D printed absorbable implant, thereby making it possible to get the desired size with just one operation. This implant helps the patient’s fat cells regenerate.
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MATTISSE is made up of two 3D printed bioabsorbable parts: the first, inspired by Calais laces, provides support for the fat, and the second is a shell giving the volume and the shape reconstruction.

The use of 3D printing makes it possible, using MRI or CT-scan images, to design a personalised implant to restore former breast.
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Autologous fat tissues are placed on the support material. It helps guide tissue reconstruction during 4 to 8 months. Meanwhile, the bioabsorbable implant will slowly degrade, until full resorption in one year. The breast is thus entirely rebuilt by the patient’s tissues, without introducing any foreign bodies.
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LATTICE MEDICAL’s ambition is to make and commercialize the implant for reconstruction and plastic surgery markets by 2023. The product is in the pre-clinical development stage and be tested in a first clinical breast reconstruction trial in 2021.
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The breakthrough innovation that Lattice Medical has developed was made possible by combining different skillsets in the textile materials industry, including through UP-tex, in connection with the medical and university team of CHU Lille and of Lille University.

Since January 2017, Lattice Medical has been in incubation at Eurasanté and receiving financial support from the Hauts-de-France region as well as from BPIFrance.
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APPLICATIONS

THE MAT(T)ISSE BIOPROTHESIS:
A BIO-RESORBABLE TEC
(TISSUE ENGINEERING CHAMBER)

RESORBABLE CHAMBER

Designed and made
with 3D printed biomaterials

Adapted to the individual morphology of patients

Fully degrades
in a year

PATIENT AUTOLOGOUS ADIPOSE TISSUE GRAFTING

Vascular adipose flap tissue inlaid
over the Tissue Engineering Chamber (TEC)

Guided tissue
reconstruction

Regenerates patients’
adispose cells

The desired size is reached after just one surgery: breasts are entirely reconstructed by the patient’s tissues, and no foreign bodies are introduced.

SUBCUTANEOUS TISSUE
AND FACIAL RECONSTRUCTION

Lattice Medical also provides solutions for improving tissue engineering and regenerative medicine using 3D-printed bio-resorbable scaffolds.

Following surgery, serious burns, chronic wounds, and accidents, traumatized soft tissue needs to be repaired.

In collaboration with CHU Lille, Lattice Medical provides product design, R&D services, and various solutions for soft tissue engineering and regeneration. Alongside textile manufacturing partners, we develop textile matrixes (including Calais lace ones) that are obtained through the Leavers method.

Lattice Medical offers sub-licensing R&D contracts to manufacturers and provides pre-clinical proof-of-concept studies.

SOFT TISSUE RECONSTRUCTION PLATFORM

A new era in medical application development

Thanks to its integrated platform, Lattice Medical is able to offer innovative solutions and the opportunity for biomedical projects to explore new technological landscapes. Lattice Medical is helping manufacturers in the medical procedure industry with their transition towards 3D technology.
Lattice Medical is developing the first ISO 13485 production in clean room with 3D printing for designing personalized implantable resorbable medical devices.
This unique platform is endowed with new 3D printing and extrusion technology that is able to produce prototypes, pre-series and industrial series for R&D trials, pre-clinical and clinical studies at extremely low particular pollution levels.

SERVICES

E-SHOP

FILAMENTS FOR 3D PRINTING

Want to test specific medical grade polymers for R&D purpose in 3D printing medical area such as tissue engineering, custom medical devices or 3D printed prototypes. Try our filaments for 3D printing.

ACCESS TO THE E-SHOP

TEAM

Justine Bax

Quality and Regulatory Affairs

Kévin ROUX

Process Engineer

Shengheng Cao

Biomedical Engineer

Dr. Pierre-Marie Danzé

Biochemist, Co-Founder and Scientific Advisor

Jaime Destouesse-Villa

Mechanical Engineer

Marion Gradwohl

Material Engineer

Pr. Pierre Guerreschi

Plastic and Reconstructive Surgeon, Co-Founder and Scientific Advisor

Pr. Philippe Marchetti

Biologist, Co-Founder and Scientific Advisor

Claire Nahon

Pre-clinical Studies

Julien Payen

CEO, Co-founder

Guillaume Bruniaux

Mission Director at SIPAREX for Nord France Amorçage

Hélène Cannard

Member of the executive management at FINOVAM GESTION

François Martin

Associate Partner with Schnopp & Partner

Nicolas Blanchemain

Assistant Professor at Lille University, Biomaterials, Medical Devices and Drug Delivery

Pr. Mathias Brieu

Professor at Cal State Los Angeles, Mechanical Engineering

Pr. Xavier Garric

Professor at Montpelier University, Artificial Biopolymers

Dr. Nicolas Leymarie

Plastic and Reconstructive Surgeon, Gustave Roussy

Isabelle Martinache

Tissue referring doctor, French Biomedicine Agency

Pr. Michel Toungouz

Center for Tissue and Cell Therapy, Head of Clinic, Saint Luc and Bruxelles University

PRESS REPORT

Publication of LATTICE MEDICAL on 3DMedNet journal

Many thanks to the 3DMedNet journal for their article on LATTICE MEDICAL in the last issue : “Applications of 3D printing in oncology: breast and soft tissue reconstruction”

Source : 3DMedNet https://www.3dmednet.com/users/14012-3dmednet/posts/42784-applications-of-3d-printing-in-oncology-breast-and-soft-tissue-reconstruction

LATTICE MEDICAL RÉUNIT 2,3 MILLIONS POUR SES BIOPROTHÈSES MAMMAIRES

“La première bioprothèse à régénération cellulaire pour la reconstruction mammaire a été mise au point par la jeune entreprise lilloise Lattice Medical. Elle vient de boucler un financement de 2,3 millions d’euros pour valider son dispositif médical et mener les essais cliniques nécessaires à l’obtention du marquage CE.”

Source : Les Echos, Lattice Medical réunit 2,3 millions pour ses bioprothèses mammaires

UNE NOUVELLE VIE APRÈS LE CANCER DU SEIN : LE DÉFI DE LATTICE MEDICAL

“Lattice Medical, pépite des Hauts-de-France soutenue par la Région, met au point une bioprothèse implantable pour la reconstruction mammaire. Une innovation qui permettrait à des milliers de femmes de retrouver, une fois le cancer du sein vaincu, une vie après la maladie.”

Source : Hauts-de-France, Une nouvelle vie après le cancer du sein : le défi de Lattice Medical

RENCONTRE AVEC LATTICE MEDICAL : L'IMPRESSION 3D ET LA DENTELLE POUR RÉVOLUTIONNER LA RECONSTRUCTION MAMMAIRE

“Seules 15 % des 1,7 millions de femmes touchées chaque année dans le monde par le cancer bénéficient d’une reconstruction mammaire. Pour offrir une alternative aux possibilités thérapeutiques classiques particulièrement coûteuses et lourdes en chirurgie, une jeune pousse tricolore du nom Lattice Medical a imaginé une prothèse imprimée en 3D 100 % bio-résorbable et personnalisable.”

Source : Primante 3D, Rencontre avec Lattice Medical, l’impression et la dentelle pour révolutionner la reconstruction mammaire

NEWS

LATTICE MEDICAL est sélectionné pour pitcher lors des journées Start-Up du DM organisées par le SNITEM

LATTICE MEDICAL fait partie des 12 lauréats sélectionnés par le SNITEM pour pitcher et avoir son stand lors des journées Start-UP du Dispositif Médical organisées le 14 mai à la cité des sciences de Paris.

Source : https://www.snitem.fr/startup2019

LATTICE MEDICAL team moves in new offices

The whole LATTICE MEDICAL team has moved in our new offices in the Eurasanté Park in the heart of Lille Hospitals (CHU Lille). We are glad to have 300 m² space and a dedicated space of 70 m² for our 3D printing platform. Few months of works and we will be able to inaugurate the new offices.

JANUARY 2019 - HAPPY NEW YEAR !

The whole team LATTICE MEDICAL wishes you all the best for the year 2019. LATTICE MEDICAL ends 2018 with a lot of great things:

Winner of 4 contests: Ruban Rose, Force Awards, Fondation Béatrice Denys, i-Lab
First seed fund raising
Moving in new facilities
Team growth
Development acceleration with more pre-clinical trials and more capacity of prototyping

2019 will be for us a 200% year with the same desire to bring a new solution for all patients wishing to obtain a natural breast reconstruction.

Happy New Year !

NOVEMBER 2018 - FIRST SEED ROUND

LATTICE MEDICAL is proud to announce the closing of our first seed round. It will help us accelerate the pre-clinical phase of the project. We would like to thank the commitment of the investment funds and their investors in our project: Finovam, FIRA Nord Est, NORD FRANCE AMORCAGE and WiSEED. We also thank the support of Bpifrance through various funding tools and competitions that makes it possible to complete a first round of funding for a total of 2.3 million euros. We are still on the way to bring a real solution and a revolution in breast reconstruction.

LATTICE MEDICAL EXPOSED AT MEDFIT EXHIBITION

LATTICE MEDICAL exposed at the MEDFIT exhibition, special in innovative medical devices, on 26 and 27 June in Strasbourg. It was the first trade show for the company displaying its products. We had the opportunity to present our product in front of a jury of professionals (J & J, MEDTRONIC, URGO) for which he was very well received and encouraged. We had more than 150 visits to our booth over the two days and made many contacts.